LVGRQLEEFL (mouse) (TFA)

• UNSPSC Description:

  LVGRQLEEFL (mouse) TFA can be named as G * peptide, corresponding to amino acids 113 to 122 in apolipoprotein J ([113,122] apoJ)}. LVGRQLEEFL (mouse) TFA exhibits anti-inflammatory and anti-atherogenic properties. LVGRQLEEFL (mouse) TFA can be added to an apoJ mimetic, to form HM-10/10 peptide, which is a mimetic peptide and a novel chimeric high density lipoprotein. HM-10/10 peptide protects retinal pigment epithelium (RPE) and photoreceptors from oxidant induced cell death[1][2].

• Target Antigen:

  Amino Acid Derivatives; Apolipoprotein

• Type:

  Peptides

• Related Pathways:

  Metabolic Enzyme/Protease;Others

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/lvgrqleefl-mouse-tfa.html

• Purity:

  98.20

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C([C@@H](N)CC(C)C)N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CC(C)C)=O)CC1=CC=CC=C1)=O)CCC(O)=O)=O)CCC(O)=O)=O)CC(C)C)=O)CCC(N)=O)=O)CCCNC(N)=N)=O)=O)C(C)C.OC(C(F)(F)F)=O.[x]

• Molecular Weight:

  1203.39 (free acid)

• References & Citations:

  [1]Su F, et al. A Novel HDL-Mimetic Peptide HM-10/10 Protects RPE and Photoreceptors in Murine Models of Retinal Degeneration. Int J Mol Sci. 2019 Sep 27;20(19):4807. |[2]Mishra VK, et al. Structure and lipid interactions of an anti-inflammatory and anti-atherogenic 10-residue class G(*) apolipoprotein J peptide using solution NMR. Biochim Biophys Acta. 2011 Jan;1808(1):498-507.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)

• Clinical Information:

  No Development Reported