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LVGRQLEEFL (mouse) (TFA)

CAT: 0804-HY-P5169ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P5169ASize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LVGRQLEEFL (mouse) TFA can be named as G * peptide, corresponding to amino acids 113 to 122 in apolipoprotein J ([113,122] apoJ) }. LVGRQLEEFL (mouse) TFA exhibits anti-inflammatory and anti-atherogenic properties. LVGRQLEEFL (mouse) TFA can be added to an apoJ mimetic, to form HM-10/10 peptide, which is a mimetic peptide and a novel chimeric high density lipoprotein. HM-10/10 peptide protects retinal pigment epithelium (RPE) and photoreceptors from oxidant induced cell death[1][2].
UNSPSC
12352209
Target
Amino Acid Derivatives; Apolipoprotein
Type
Peptides
Related Pathways
Metabolic Enzyme/Protease; Others
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/lvgrqleefl-mouse-tfa.html
Purity
98.20
Solubility
10 mM in DMSO
Smiles
O=C([C@@H](N)CC(C)C)N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CC(C)C)=O)CC1=CC=CC=C1)=O)CCC(O)=O)=O)CCC(O)=O)=O)CC(C)C)=O)CCC(N)=O)=O)CCCNC(N)=N)=O)=O)C(C)C.OC(C(F)(F)F)=O.[x]
Molecular Formula
C55H90N14O16.xC2HF3O2
Molecular Weight
1203.39 (free acid)
References & Citations
[1]Su F, et al. A Novel HDL-Mimetic Peptide HM-10/10 Protects RPE and Photoreceptors in Murine Models of Retinal Degeneration. Int J Mol Sci. 2019 Sep 27;20 (19) :4807. |[2]Mishra VK, et al. Structure and lipid interactions of an anti-inflammatory and anti-atherogenic 10-residue class G (*) apolipoprotein J peptide using solution NMR. Biochim Biophys Acta. 2011 Jan;1808 (1) :498-507.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Scientific Category
Peptides
Clinical Information
No Development Reported

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