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Cyclo (CRLLIF)

CAT: 0804-HY-P10222Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P10222Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cyclo CRLLIF is a dual inhibitor for hypoxia inducible factor (HIF) 1 and 2, which disrupts the interaction of both HIF1-α and HIF2-α with HIF1-β, with affinity for HIF1-α and HIF2-α PAS-B domains KD of 14.5 and 10.2 μM, respectively[1].
UNSPSC
12352209
Target
HIF/HIF Prolyl-Hydroxylase
Type
Peptides
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cyclo-crllif.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H]([C@@H](C)CC)C(N[C@H]1CC2=CC=CC=C2)=O)=O)=O)=O)[C@H](CS)NC1=O
Molecular Formula
C36H59N9O6S
Molecular Weight
745.98
References & Citations
[1]Ball AT, et al., Identification and Development of Cyclic Peptide Inhibitors of Hypoxia Inducible Factors 1 and 2 That Disrupt Hypoxia-Response Signaling in Cancer Cells. J Am Chem Soc. 2024 Mar 19.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
HIF

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