Cyclo (RGDyK)

CAT: 0804-HY-100563A-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-100563A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cyclo (RGDyK) is a potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM.
CAS Number
[217099-14-4]
UNSPSC
12352209
Target
Integrin
Type
Peptides
Related Pathways
Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cyclo-rgdyk.html
Purity
99.83
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
OC(C=C1)=CC=C1C[C@@H](N2)C(N[C@H](C(N[C@H](C(NCC(N[C@@H](CC(O)=O)C2=O)=O)=O)CCCNC(N)=N)=O)CCCCN)=O
Molecular Formula
C27H41N9O8
Molecular Weight
619.67
References & Citations
[1]Haubner R, et al. Glycosylated RGD-containing peptides: tracer for tumor targeting and angiogenesis imaging with improved biokinetics. J Nucl Med. 2001 Feb;42 (2) :326-36.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
αvβ3
Citation 01
Biochem Pharmacol. 2023 Nov:217:115808.|J Adv Res. 2025 May 25:S2090-1232 (25) 00370-4.|Pharmaceuticals (Basel) . 2021 Mar 14;14 (3) :260.|Stem Cell Res Ther. 2022 Jul 18;13 (1) :327.

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