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Raf1 Rabbit mAb [KD Validated] Antibody

CAT: 0013-GTR18335690-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0013-GTR18335690-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Raf-1 is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated Raf-1 can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylate to activate the serine/threonine specific protein kinases ERK1 and ERK2.
Product Name Alternative
C-RAF, C-Raf, CRAF, EC 2.7.11.1, Protein kinase raf 1, RAF1, Raf proto-oncogene serine/threonine-protein kinase, Raf-1, kinase Raf1
UniProt
P04049
Reactivity
Human, Mouse, Rat
Immunogen
A synthesized peptide derived from human Raf1
Clonality
Monoclonal
Conjugation
Unconjugated
Field of Research
Signal Transduction
Purification
Affinity-chromatography
Dilution
WB 1:1000~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200
Form
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Tested Applications
ICC, IHC, WB
Host or Source
Rabbit
Isotype
Rabbit IgG

UniProtKB · P04049

RAF proto-oncogene serine/threonine-protein kinase

RAF1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P04049
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
RAF1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.11.1
Processing
—
Secondary accessions
B0LPH8, B2R5N3, Q15278, Q9UC20
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingMetal-bindingNucleotide-bindingZinc

Disease

CardiomyopathyDeafnessDisease variantProto-oncogene

Cellular component

Cell membraneCytoplasmMembraneMitochondrionNucleus

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

PTM

MethylationPhosphoprotein

Domain

Zinc-finger

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