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Chk2 Rabbit mAb [KD Validated] Antibody

CAT: 0013-GTR18335516-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0013-GTR18335516-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
These are known to be preferred sites for phosphorylation by ATM/ATR kinases. After DNA damage by ionizing radiation (IR), UV irradiation, or hydroxyurea treatment, Thr68 and other sites in this region become phosphorylated by ATM/ATR. The SQ/TQ cluster domain, therefore, seems to have a regulatory function.
Product Name Alternative
CHEK2; CHK2; Cds1; Chk2; EC 2.7.11.1; RAD53; kinase Chk2
UniProt
O96017
Reactivity
Human
Immunogen
A synthesized peptide derived from human Chk2
Clonality
Monoclonal
Conjugation
Unconjugated
Field of Research
Cell Biology
Purification
Affinity-chromatography
Dilution
WB 1:10000~1:20000 IHC 1:50~1:200 ICC/IF 1:50~1:200 IP 1:50
Form
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Tested Applications
ICC, IHC, IP, WB
Host or Source
Rabbit
Isotype
Rabbit IgG

UniProtKB · O96017

Serine/threonine-protein kinase Chk2

CHK2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O96017
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CHEK2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.11.1
Processing
—
Secondary accessions
A8K3Y9, B7ZBF3, B7ZBF4, B7ZBF5, Q6QA03, Q6QA04, Q6QA05, Q6QA06, Q6QA07, Q6QA08, Q6QA10, Q6QA11, Q6QA12, Q6QA13, Q9HBS5, Q9HCQ8, Q9UGF0, Q9UGF1
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisCell cycleCell divisionDNA damageDNA repairHost-virus interactionMitosisTranscriptionTranscription regulation

Ligand

ATP-bindingMagnesiumMetal-bindingNucleotide-binding

Disease

Disease variantLi-Fraumeni syndromeTumor suppressor

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

Cellular component

Nucleus

PTM

PhosphoproteinUbl conjugation

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