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HDAC3 Rabbit mAb [KD Validated] Antibody

CAT: 0013-GTR18335546-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0013-GTR18335546-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HDAC3 is a nuclear and cytoplasmic protein that deacetylates both histone (H2A, H3, H4) and non-histone substrates (RelA, SRY, p53, MEF2, PCAF and p300/CBP) . HDAC3 deacetylase activity is stimulated by interactions with the N-CoR and SMRT co-repressor proteins. Together, these three proteins form a functional complex that represses transcription associated with nuclear hormone receptors and other transcription factors, including Rev-Erb, COUP-TF, DAX1, MAD and Pit-1.
Product Name Alternative
HD3; Histone deacetylase 3; RPD3-2; SMAP45; HDAC3
UniProt
O15379
Reactivity
Human, Mouse, Rat
Immunogen
A synthesized peptide derived from human HDAC3
Clonality
Monoclonal
Conjugation
Unconjugated
Field of Research
Epigenetics & Chromatin
Purification
Affinity-chromatography
Dilution
WB 1:1000~1:2000 IHC 1:50~1:100 ICC/IF 1:50~1:200 IP 1:30
Form
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Tested Applications
ICC, IHC, IP, WB
Host or Source
Rabbit
Isotype
Rabbit IgG

UniProtKB · O15379

Histone deacetylase 3

HDAC3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O15379
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
HDAC3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
HD3
EC number
3.5.1.98
Processing
—
Secondary accessions
D3DQE1, O43268, Q9UEI5, Q9UEV0
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Biological rhythmsHost-virus interactionTranscriptionTranscription regulation

Molecular function

Chromatin regulatorHydrolaseRepressor

Cellular component

ChromosomeCytoplasmNucleus

PTM

PhosphoproteinUbl conjugation

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