JAM1 Rabbit mAb [KD Validated] Antibody

CAT: 0013-GTR18335514-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0013-GTR18335514-01Size:50 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Seems to plays a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity) . Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus.

Product Name Alternative

F11R; CD321; JAM; JAM-1; JAM-A; JAM1; JAMA; JCAM; KAT; PAM-1; Junction adhesion molecule 1

UniProt

Q9Y624

Reactivity

Human, Mouse, Rat

Immunogen

A synthesized peptide derived from human JAM1

Clonality

Monoclonal

Conjugation

Unconjugated

Field of Research

Immunology & Inflammation

Purification

Affinity-chromatography

Dilution

WB 1:500~1:2000 IHC 1:50~1:200

Form

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Molecular Weight

33kDa

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Notes

For research use only.

Tested Applications

IHC, WB

Host or Source

Rabbit

Isotype

Rabbit IgG

UniProtKB · Q9Y624

Junctional adhesion molecule A

JAM1_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q9Y624
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: F11R
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: JAM-A
EC number: —
Processing: Precursor
Secondary accessions: B7Z941

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell junctionCell membraneMembraneTight junction

PTM

Disulfide bondGlycoproteinPhosphoprotein

Molecular function

Host cell receptor for virus entryReceptor

Biological process

Host-virus interaction

Domain

Immunoglobulin domainRepeatSignalTransmembraneTransmembrane helix

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