Products for Research Use Only
RegisterLogin

Desoximetasone (Standard)

CAT: 0804-HY-17570R-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-17570R-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Desoximetasone (Standard) is the analytical standard of Desoximetasone. This product is intended for research and analytical applications. Desoximetasone is a corticosteroid and a substrate of cytochrome P450 3A4. Desoximetasone has anti-inflammatory, anti-allergic, and immunosuppressive effects. Desoximetasone can be used in the research of various skin diseases, such as skin allergies, atopic dermatitis, and psoriasis[1].
CAS Number
382-67-2
UNSPSC
12352211
Hazard Statement
H302+H312+H332, H315, H317, H319, H335, H351
Target
Cytochrome P450; Glucocorticoid Receptor; Interleukin Related; Reference Standards
Type
Reference Standards
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/desoximetasone-standard.html
Purity
98.97
Smiles
F[C@@]1([C@]2(C=C3)C)[C@](CCC2=CC3=O)([H])[C@@](C[C@@H](C)[C@@H]4C(CO)=O)([H])[C@]4(C)C[C@@H]1O
Molecular Formula
C22H29FO4
Molecular Weight
376.46
Precautions
H302+H312+H332, H315, H317, H319, H335, H351
References & Citations
[1]Guo JW, et al. A Promising Approach to Treat Psoriasis: Inhibiting Cytochrome P450 3A4 Metabolism to Enhance Desoximetasone Therapy. Pharmaceutics. 2023 Jul 25;15 (8) :2016.
Shipping Conditions
Room Temperature
Storage Conditions
4°C, sealed storage, away from light and moisture
Scientific Category
Reference Standards
Clinical Information
Launched

Chemical Information

Desoximetasone

Desoximetasone is dexamethasone in which the hydroxy group at the 17alpha position is substituted by hydrogen. A synthetic corticosteroid with glucocorticoid activity, it is used as an anti-inflammatory and anti-pruritic in the treatment of various skin disorders, including skin allergies and psoriasis. It has a role as an anti-inflammatory drug and an antipruritic drug. It is a primary alpha-hydroxy ketone, a glucocorticoid, a 21-hydroxy steroid, an 11beta-hydroxy steroid, a 20-oxo steroid, a fluorinated steroid and a 3-oxo-Delta(1),Delta(4)-steroid.

CAS Number382-67-2
PubChem CID5311067
IUPAC Name(8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,11,12,14,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-3-one
Molecular FormulaC22H29FO4
Molecular Weight376.5
XLogP2.3
Topological Polar Surface Area74.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Heavy Atom Count27
Formal Charge0
Complexity757
SMILES
C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@H]1C(=O)CO)C)O)F)C
InChI
InChI=1S/C22H29FO4/c1-12-8-16-15-5-4-13-9-14(25)6-7-21(13,3)22(15,23)18(27)10-20(16,2)19(12)17(26)11-24/h6-7,9,12,15-16,18-19,24,27H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,18+,19-,20+,21+,22+/m1/s1
InChIKey
VWVSBHGCDBMOOT-IIEHVVJPSA-N
Chemical Structure
2D Structure
2D structure of Desoximetasone
CAS: 382-67-2
CID: 5311067
Formula: C22H29FO4
MW: 376.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight376.5
XLogP32.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Exact Mass376.20498756
Monoisotopic Mass376.20498756
Topological Polar Surface Area74.6 Ų
Heavy Atom Count27
Formal Charge0
Complexity757
Isotope Atom Count0
Defined Atom Stereocenter Count8
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-17570-01Desoximetasone
HY-P2274RArgifin (Standard)
HY-N9362REmodinanthrone (Standard)
HY-N7948RIsomaltotetraose (Standard)
HY-N7640RDeoxylimonin (Standard)
HY-N7617RToralactone (Standard)
HY-N7541RAntrodin A (Standard)
HY-N6739RBeauvericin (Standard)
HY-N6687RCalcimycin (Standard)
HY-N3373RLoganetin (Standard)

Alternative Products

CatalogName
317590Desoximetasone
A17733-25Desoximetasone 25mg
AR-D01507-01Desoximetasone Sulfate
A17733-50Desoximetasone 50mg
A17733-5Desoximetasone 5mg
A17733-10Desoximetasone 10mg
AR-D01494-01Desoximetasone-d3
AR-D01497-01Desoximetasone Impurity A
A17733-500Desoximetasone 500mg
A17733-100Desoximetasone 100mg

Popular Products