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Desoximetasone

CAT: 0804-HY-17570-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-17570-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Desoximetasone is a corticosteroid and a substrate of cytochrome P450 3A4. Desoximetasone has anti-inflammatory, anti-allergic, and immunosuppressive effects. Desoximetasone can be used in the research of various skin diseases, such as skin allergies, atopic dermatitis, and psoriasis[1][2].
CAS Number
382-67-2
UNSPSC
12352211
Hazard Statement
H302+H312+H332, H315, H317, H319, H335, H351
Target
Cytochrome P450; Glucocorticoid Receptor; Interleukin Related
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/desoximetasone.html
Purity
99.52
Solubility
DMSO : ≥ 100 mg/mL|H2O : 0.14 mg/mL (ultrasonic)
Smiles
F[C@@]1([C@]2(C=C3)C)[C@](CCC2=CC3=O)([H])[C@@](C[C@@H](C)[C@@H]4C(CO)=O)([H])[C@]4(C)C[C@@H]1O
Molecular Formula
C22H29FO4
Molecular Weight
376.46
Precautions
H302+H312+H332, H315, H317, H319, H335, H351
References & Citations
[1]Guo JW, et al. Magnolol may contribute to barrier function improvement on imiquimod-induced psoriasis-like dermatitis animal model via the downregulation of interleukin-23. Exp Ther Med. 2021 May;21 (5) :448.|[2]Guo JW, et al. A Promising Approach to Treat Psoriasis: Inhibiting Cytochrome P450 3A4 Metabolism to Enhance Desoximetasone Therapy. Pharmaceutics. 2023 Jul 25;15 (8) :2016.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
IL-1; IL-13; IL-6

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