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PAR 4 (1-6) (human)

CAT: 0804-HY-P1313-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P1313-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PAR 4 (1-6) human, a hexapeptide, is a fragment of protease-activated receptor 4 (PAR4) . PAR 4 (1-6) TFA acts as a PAR4-specific agonist[1].
CAS Number
225779-44-2
Product Name Alternative
GYPGQV
UNSPSC
12352209
Target
Protease Activated Receptor (PAR)
Type
Peptides
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/par-4-1-6-human.html
Solubility
10 mM in DMSO
Smiles
OC(C=C1)=CC=C1C[C@H](NC(CN)=O)C(N2[C@@H](CCC2)C(NCC(N[C@@H](CCC(N)=O)C(N[C@H](C(O)=O)C(C)C)=O)=O)=O)=O
Molecular Formula
C28H41N7O9
Molecular Weight
619.67
References & Citations
[1]H Andersen, et al. Protease-activated receptor 1 is the primary mediator of thrombin-stimulated platelet procoagulant activity. Proc Natl Acad Sci U S A. 1999 Sep 28;96 (20) :11189-93.|[2]E Bretschneider, et al. Evidence for functionally active protease-activated receptor-4 (PAR-4) in human vascular smooth muscle cells. Br J Pharmacol. 2001 Apr;132 (7) :1441-6.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

Chemical Information

H-Gly-tyr-pro-gly-gln-val-OH
CAS Number225779-44-2
PubChem CID10240159
IUPAC Name(2S)-2-[[(2S)-5-amino-2-[[2-[[(2S)-1-[(2S)-2-[(2-aminoacetyl)amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]-5-oxopentanoyl]amino]-3-methylbutanoic acid
Molecular FormulaC28H41N7O9
Molecular Weight619.7
XLogP-4.1
Topological Polar Surface Area263
Hydrogen Bond Donor Count8
Hydrogen Bond Acceptor Count10
Rotatable Bond Count16
Heavy Atom Count44
Formal Charge0
Complexity1060
SMILES
CC(C)[C@@H](C(=O)O)NC(=O)[C@H](CCC(=O)N)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)CN
InChI
InChI=1S/C28H41N7O9/c1-15(2)24(28(43)44)34-25(40)18(9-10-21(30)37)32-23(39)14-31-26(41)20-4-3-11-35(20)27(42)19(33-22(38)13-29)12-16-5-7-17(36)8-6-16/h5-8,15,18-20,24,36H,3-4,9-14,29H2,1-2H3,(H2,30,37)(H,31,41)(H,32,39)(H,33,38)(H,34,40)(H,43,44)/t18-,19-,20-,24-/m0/s1
InChIKey
VTCFYKYDKDAJKZ-XHOYROJHSA-N
Chemical Structure
2D Structure
2D structure of H-Gly-tyr-pro-gly-gln-val-OH
CAS: 225779-44-2
CID: 10240159
Formula: C28H41N7O9
MW: 619.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight619.7
XLogP3-4.1
Hydrogen Bond Donor Count8
Hydrogen Bond Acceptor Count10
Rotatable Bond Count16
Exact Mass619.29657591
Monoisotopic Mass619.29657591
Topological Polar Surface Area263 Ų
Heavy Atom Count44
Formal Charge0
Complexity1060
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
GTR19144355-01PAR3 (1-6) (human)
H-4348.0005PAR-4 (1-6) (human)
H-4452.0100PAR-3 (1-6) (human)
T76650PAR-2 (1-6) (human)
MBS5818576PAR-2 (1-6)(human)
GTR18894358Human PAR4 (1-6) peptide
GTR18890260Human PAR2 (6-1) peptide
GTR18890258Human PAR2 (1-6) peptide
E-PP-1719-01PAR-3 (1-6), human
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