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PAR-2 (1-6) (human)

CAT: 0804-HY-P4803-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P4803-01Size:1 mg
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Description
PAR-2 (1-6) (human) (SLIGKV), a peptide ligand, is a PAR-2 agonist[1].
CAS Number
202933-49-1
UNSPSC
12352209
Target
Protease Activated Receptor (PAR)
Type
Peptides
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/par-2-1-6-human.html
Purity
99.74
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
OC[C@H](N)C(N[C@@H](CC(C)C)C(N[C@@H]([C@@H](C)CC)C(NCC(N[C@@H](CCCCN)C(N[C@H](C(O)=O)C(C)C)=O)=O)=O)=O)=O
Molecular Formula
C28H53N7O8
Molecular Weight
615.76
References & Citations
[1]Belinda Liu, et al. The PAR2 signal peptide prevents premature receptor cleavage and activation. PLoS One. 2020 Feb 20;15 (2) :e0222685.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Scientific Category
Peptides
Clinical Information
No Development Reported

Chemical Information

Seryl-leucyl-isoleucyl--glycyl-lysyl-valine

derived from amino-terminus of proteinase-activated receptor 2 (PAR-2)

CAS Number202933-49-1
PubChem CID10232703
IUPAC Name(2S)-2-[[(2S)-6-amino-2-[[2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-methylpentanoyl]amino]acetyl]amino]hexanoyl]amino]-3-methylbutanoic acid
Molecular FormulaC28H53N7O8
Molecular Weight615.8
XLogP-2.4
Topological Polar Surface Area255
Hydrogen Bond Donor Count9
Hydrogen Bond Acceptor Count10
Rotatable Bond Count21
Heavy Atom Count43
Formal Charge0
Complexity931
SMILES
CC[C@H](C)[C@@H](C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)N
InChI
InChI=1S/C28H53N7O8/c1-7-17(6)23(35-26(40)20(12-15(2)3)33-24(38)18(30)14-36)27(41)31-13-21(37)32-19(10-8-9-11-29)25(39)34-22(16(4)5)28(42)43/h15-20,22-23,36H,7-14,29-30H2,1-6H3,(H,31,41)(H,32,37)(H,33,38)(H,34,39)(H,35,40)(H,42,43)/t17-,18-,19-,20-,22-,23-/m0/s1
InChIKey
NTQVODZUQIATFS-WAUHAFJUSA-N
Chemical Structure
2D Structure
2D structure of Seryl-leucyl-isoleucyl--glycyl-lysyl-valine
CAS: 202933-49-1
CID: 10232703
Formula: C28H53N7O8
MW: 615.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight615.8
XLogP3-2.4
Hydrogen Bond Donor Count9
Hydrogen Bond Acceptor Count10
Rotatable Bond Count21
Exact Mass615.39556167
Monoisotopic Mass615.39556167
Topological Polar Surface Area255 Ų
Heavy Atom Count43
Formal Charge0
Complexity931
Isotope Atom Count0
Defined Atom Stereocenter Count6
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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