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LL-K-12-18

CAT: 0931-T210520-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T210520-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
CDK
Related Pathways
Cell Cycle/Checkpoint
Purity
0.9977
Bioactivity
LL-K12-18 is a two-site molecular glue that enhances interaction between CDK12 and DDB1, stabilizing the complex and promoting selective degradation of cyclin K with an EC50 of 0.37 nM. It exhibits potent transcriptional repression and antiproliferative effects in tumor models, making it a valuable chemical tool for investigating transcriptional regulation and targeted protein degradation in cancer research.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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