Heteropodatoxin-2 (TFA)

Heteropodatoxin-2 (TFA)

• UNSPSC Description: Heteropodatoxin-2 (TFA), a peptides of 30-amino acid, is a heteropodatoxin. Heteropodatoxin-2 blocks Kv4.2 current expressed in Xenopus laevis oocytes in a voltage-dependent manner, with less block at more positive potentials[1].
• Target Antigen: Potassium Channel
• Type: Peptides
• Related Pathways: Membrane Transporter/Ion Channel
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/heteropodatoxin-2-tfa.html
• Purity: 97.43
• Solubility: H2O : ≥ 50 mg/mL
• Smiles: O=C([C@@H](N)CC(O)=O)N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]1CSSC[C@H](NC2=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CC3=CNC4=CC=CC=C34)=O)CC(O)=O)=O)CC(C)C)=O)CCCCN)=O)=O)CC(O)=O)=O)C)=O)CC(N)=O)=O)[C@@H](C)O)=O)CC(O)=O)=O)CSSC[C@H](NC5=O)C(N[C@H](C(N[C@H](C(N[C@H]2CC6=CNC7=CC=CC=C67)=O)CC(C)C)=O)CCCNC(N)=N)=O)=O)=O)CO)=O)CC8=CC=CC=C8)=O)CC(C)C)=O)CCCCN)=O)=O)CSSC[C@H](NC1=O)C(N[C@H](C(NCC(N[C@H](C(N[C@H]5C(C)C)=O)CC9=CC=C(O)C=C9)=O)=O)CCC(O)=O)=O)=O)CC(O)=O.O=C(C(F)(F)F)O.[x]
• Molecular Weight: 3412.81 (free base)
• References & Citations: [1]M C Sanguinetti, et al. Heteropodatoxins: peptides isolated from spider venom that block Kv4.2 potassium channels. Mol Pharmacol. 1997 Mar;51(3):491-8.
• Shipping Conditions: Blue Ice
• Storage Conditions: -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
• Clinical Information: No Development Reported