Heteropodatoxin-1

Heteropodatoxin-1

• UNSPSC Description: Heteropodatoxin-1 (HpTx1), a spider peptide toxin, is a Kv4.2 current inhibitor. Heteropodatoxin-1 also inhibits Nav1.7 and activates Nav1.9 but does not affect Nav1.8[1].
• Target Antigen: Potassium Channel; Sodium Channel
• Type: Peptides
• Related Pathways: Membrane Transporter/Ion Channel
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/heteropodatoxin-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCC(O)=O)C(NCC(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@H]3CCCCN)=O)=O)=O)=O)NC4=O)C(NCC(N[C@@H]([C@H](O)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC5=CNC6=CC=CC=C56)C(N[C@@H](CC7=CNC=N7)C(N[C@@H](CC8=CC=C(C=C8)O)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@H]9CC(C)C)=O)=O)=O)=O)NC3=O)C(NCC(N[C@@H]([C@H](O)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CO)C(N[C@@H](CCC(O)=O)C(N[C@H]4CSSC[C@@H](C(N[C@@H](CCCCN)C(N[C@@H](CC%10=CC=C(C=C%10)O)C(N[C@@H](C(C)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(O)=O)C(N[C@@H](CC%11=CNC%12=CC=CC=C%11%12)C(N)=O)=O)=O)=O)=O)=O)=O)NC9=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(O)=O)N
• Molecular Weight: 3910.35
• References & Citations: [1]Xi Zhou, et al. Spider venom-derived peptide induces hyperalgesia in Nav1.7 knockout mice by activating Nav1.9 channels. Nat Commun. 2020 May 8;11(1):2293.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported