Secalciferol-d6

Secalciferol-d6 is the deuterium labeled Secalciferol. Secalciferol is a metabolite of Vitamin D, a possibly anti-inflammatory steroid which is involved in bone ossification[1][2].

1440957-55-0

(24R) -24,25-Dihydroxyvitamin D3-d6

12352211

Endogenous Metabolite; Isotope-Labeled Compounds; VD/VDR

Isotope-Labeled Compounds

Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor

COVID-19-immunoregulation

Inflammation/Immunology

10 mM in DMSO

C[C@@]12[C@](\C(=C\C=C\3/C(=C)CC[C@H](O)C3)\CCC1)(CC[C@@]2([C@@H](CC[C@H](C(C([2H])([2H])[2H])(C([2H])([2H])[2H])O)O)C)[H])[H]

C27H38D6O3

422.68

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Yamamoto T, Ozono K, Shima M, et al. 24R,25-dihydroxyvitamin D3 increases cyclic GMP contents, leading to an enhancement of osteocalcin synthesis by 1,25-dihydroxyvitamin D3 in cultured human osteoblastic cells. Exp Cell Res. 1998 Oct 10;244 (1) :71-6.|[3]Sakaki T, Sawada N, Takeyama K, et al. Enzymatic properties of mouse 25-hydroxyvitamin D3 1 α-hydroxylase expressed in Escherichia coli. Eur J Biochem. 1999 Feb;259 (3) :731-8.|[4]Norman AW, Okamura WH, Bishop JE, Henry HL. Update on biological actions of 1α,25 (OH) 2-vitamin D3 (rapid effects) and 24R,25 (OH) 2-vitamin D3. Mol Cell Endocrinol. 2002 Nov 29;197 (1-2) :1-13|[5]Hurst-Kennedy J, Zhong M, Gupta V et al. 24R,25-Dihydroxyvitamin D3, lysophosphatidic acid, and p53: a signaling axis in the inhibition of phosphate-induced chondrocyte apoptosis. J Steroid Biochem Mol Biol. 2010 Oct;122 (4) :264-71.|[6]Wehmeier KR, Alamir AR, Sultan S, et al. 24, 25-dihydroxycholecalciferol but not 25-hydroxycholecalciferol suppresses apolipoprotein A-I gene expression. Life Sci. 2011 Jan 3;88 (1-2) :110-6.|[7]Rubin LP, Yeung B, Vouros P et al. Evidence for human placental synthesis of 24,25-dihydroxyvitamin D3 and 23,25-dihydroxyvitamin D3. Pediatr Res. 1993 Jul;34 (1) :98-104.

Room temperature

Isotope-Labeled Compounds