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Secalciferol

CAT: 0804-HY-32343-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-32343-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Secalciferol ((24R) -24,25-Dihydroxyvitamin D3) is the major active metabolite of Vitamin D. Secalciferol activates vitamin D receptor (VDR) with an EC50 value of 150 nM. Secalciferol is involved in a wide range of biological functions such as calcium homeostasis, cellular differentiation and proliferation processes, as well as other functions related to the immune system, which is promising for research of rickets, osteomalacia, hypercalcemia and autoimmune disorders[1][2][3][4][5].
CAS Number
55721-11-4
Product Name Alternative
(24R) -24,25-Dihydroxyvitamin D3
UNSPSC
12352211
Hazard Statement
H301+H311, H330, H372
Target
Endogenous Metabolite; VD/VDR
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Secalciferol.html
Purity
99.85
Solubility
DMSO : 100 mg/mL (ultrasonic) |Ethanol : 50 mg/mL (ultrasonic)
Smiles
C=C(CC1)/C(C[C@H]1O)=C\C=C2[C@@]3([H])[C@@](CCC\2)(C)[C@@H]([C@H](C)CC[C@@H](O)C(C)(C)O)CC3
Molecular Formula
C27H44O3
Molecular Weight
416.64
Precautions
H301+H311, H330, H372
References & Citations
[1]Ono T, et al. 24R,25-dihydroxyvitamin D3 promotes bone formation without causing excessive resorption in hypophosphatemic mice[J]. Endocrinology. 1996 Jun;137 (6) :2633-7.|[2]Higashi T, et al. In vitro and in vivo glucuronidation of 24,25-dihydroxyvitamin D3[J]. Steroids. 1999 Oct;64 (10) :715-25.|[3]Bartonkova I, et al. Profiling of Vitamin D Metabolic Intermediates toward VDR Using Novel Stable Gene Reporter Cell Lines IZ-VDRE and IZ-CYP24[J]. Chem Res Toxicol. 2016 Jul 18;29 (7) :1211-22.|[4]Ikezaki S, et al. Influences of long-term administration of 24R, 25-dihydroxyvitamin D3, a vitamin D3 derivative, in rats[J]. J Toxicol Sci. 1999 May;24 (2) :133-9.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite

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