Secalciferol

• UNSPSC Description:

  Secalciferol ((24R)-24,25-Dihydroxyvitamin D3) is the major active metabolite of Vitamin D. Secalciferol activates vitamin D receptor (VDR) with an EC50 value of 150 nM. Secalciferol is involved in a wide range of biological functions such as calcium homeostasis, cellular differentiation and proliferation processes, as well as other functions related to the immune system, which is promising for research of rickets, osteomalacia, hypercalcemia and autoimmune disorders[1][2][3][4][5].

• Target Antigen:

  Endogenous Metabolite; VD/VDR

• Type:

  Natural Products

• Related Pathways:

  Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Metabolic Disease; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/Secalciferol.html

• Purity:

  99.89

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)|Ethanol : 50 mg/mL (ultrasonic)

• Smiles:

  C=C(CC1)/C(C[C@H]1O)=C\C=C2[C@@]3([H])[C@@](CCC\2)(C)[C@@H]([C@H](C)CC[C@@H](O)C(C)(C)O)CC3

• Molecular Weight:

  416.64

• References & Citations:

  [1]Ono T, et al. 24R,25-dihydroxyvitamin D3 promotes bone formation without causing excessive resorption in hypophosphatemic mice[J]. Endocrinology. 1996 Jun;137(6):2633-7.|[2]Higashi T, et al. In vitro and in vivo glucuronidation of 24,25-dihydroxyvitamin D3[J]. Steroids. 1999 Oct;64(10):715-25.|[3]Bartonkova I, et al. Profiling of Vitamin D Metabolic Intermediates toward VDR Using Novel Stable Gene Reporter Cell Lines IZ-VDRE and IZ-CYP24[J]. Chem Res Toxicol. 2016 Jul 18;29(7):1211-22.|[4]Ikezaki S, et al. Influences of long-term administration of 24R, 25-dihydroxyvitamin D3, a vitamin D3 derivative, in rats[J]. J Toxicol Sci. 1999 May;24(2):133-9.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, protect from light, stored under nitrogen)

• Clinical Information:

  No Development Reported

• CAS Number:

  55721-11-4