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Curcumin-d6

CAT: 0804-HY-N0005S-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0005S-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Curcumin-d6 (Diferuloylmethane-d6) is deuterium labeled Curcumin. Curcumin (Diferuloylmethane), a natural phenolic compound, is a p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. Curcumin is a photosensitizer against microorganisms. Curcumin shows inhibitory effects on NF-κB and MAPKs, and has diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification.
CAS Number
1246833-26-0
Product Name Alternative
Diferuloylmethane-d6; Natural Yellow 3-d6; Turmeric yellow-d6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; Epigenetic Reader Domain; Ferroptosis; Histone Acetyltransferase; Influenza Virus; Isotope-Labeled Compounds; Keap1-Nrf2; Mitophagy
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Apoptosis; Autophagy; Epigenetics; NF-κB; Others
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection; Metabolic Disease; Inflammation/Immunology
Purity
99.78
Solubility
DMSO : 100 mg/mL (ultrasonic; warming)
Smiles
O=C(CC(/C=C/C1=CC=C(O)C(OC([2H])([2H])[2H])=C1)=O)/C=C/C2=CC=C(O)C(OC([2H])([2H])[2H])=C2
Molecular Formula
C21H14D6O6
Molecular Weight
374.42
Precautions
H302, H315, H319, H335
References & Citations
[1]Gao S, et al. Curcumin attenuates arsenic-induced hepatic injuries and oxidative stress in experimental mice through activation of Nrf2 pathway, promotion of arsenic methylation and urinary excretion. Food Chem Toxicol. 2013 Jul 18. pii: S0278-6915 (13) 004.|[2]Nasiri M, et al. Curcumin and Silibinin Inhibit Telomerase Expression in T47D Human Breast Cancer Cells. Asian Pac J Cancer Prev. 2013;14 (6) :3449-53.|[3]Jiang H, et al. Antidepressant-like effects of curcumin in chronic mild stress of rats: Involvement of its anti-inflammatory action. Prog Neuropsychopharmacol Biol Psychiatry. 2013 Jul 20. pii: S0278-5846 (13) 00150-4.|[4]Guo H, et al. Curcumin induces cell cycle arrest and apoptosis of prostate cancer cells by regulating the expression of IkappaBalpha, c-Jun and androgen receptor. Pharmazie. 2013 Jun;68 (6) :431-4.|[5]Zhu X, et al. Curcumin alleviates neuropathic pain by inhibiting p300/CBP histone acetyltransferase activity-regulated expression of BDNF and cox-2 in a rat model. PLoS One. 2014 Mar 6;9 (3) :e91303.|[6]Lucas D. Dias, et al. Curcumin as a photosensitizer: From molecular structure to recent advances in antimicrobial photodynamic therapy. Journal of Photochemistry and Photobiology C: Photochemistry Reviews. Volume 45, December 2020, 100384.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
CBP/p300

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