Anti-PMEPA1 / TMEPAI (Tumor Suppressor Oncoprotein)(PMEPA1/2697), CF488A conjugate

• Description:

  PMEPA1 (prostate transmembrane protein, androgen induced 1 is a 287 amino acid single-pass membrane protein that contains WW-binding motifs and localizes to the cell membrane. Expressed at high levels in prostate, kidney and ovary, PMEPA1 interacts with NEDD4 and may play a role in regulating AR (androgen receptor) levels, specifically in prostate cells. Down regulation of PMEPA1 is observed in prostate tumors, suggesting that PMEPA1 may exhibit activity as a tumor suppressor. Overexpression of this protein may play a role in multiple types of cancer._x000D_ _x000D_ Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors._x000D_ _x000D_

• Synonyms:

  PMEPA; PMEPA1; Prostate transmembrane protein; androgen induced 1; Solid tumor-associated 1 protein; STAG1; TMEPAI; Transmembrane prostate androgen-induced protein; Transmembrane; prostate androgen induced RNA

• CAS Number:

  9007-83-4

• UNSPSC:

  41116161

• UNSPSC Description:

  Primary and secondary antibodies for multiple methodology immunostaining detection application

• Gene Name:

  PMEPA1

• Gene ID:

  56937

• NCBI Gene ID:

  517155

• UniProt:

  Q96W9

• Cellular Locus:

  Membrane/vesicular

• Host:

  Mouse

• Species Reactivity:

  Human

• Immunogen:

  Recombinant full-length human PMEPA1 protein

• Target Antigen:

  PMEPA1 | TMEPAI

• Clonality:

  Monoclonal

• Isotype:

  IgG κ

• Clone:

  PMEPA1/2697

• Conjugation:

  CF488A

• Disease:

  Tumor

• Source:

  Animal

• Applications:

  IHC, FFPE (verified)

• Validated Applications:

  IHC, FFPE

• Positive Control:

  SKBR-3 cells. Prostate, Breast or Renal Cell Carcinoma.

• Concentration:

  0.1 mg/mL

• Buffer:

  PBS, 0.1% BSA, 0.05% azide

• Molecular Weight:

  32 kDa

• Shipping Conditions:

  Room temperature

• Storage Conditions:

  4°C; Protect from light; Stable at room temperature or 37°C (98°F) for 7 days.

• Shelf Life:

  2 years