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TMEPAI Antibody / PMEPA1

CAT: 0800-V7329-20UGSize: 20 µgDry Ice: NoHazardous: No
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CAT#:0800-V7329-20UGSize:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PMEPA1 (prostate transmembrane protein, androgen induced 1), or TMEPAI (Transmembrane prostate androgen induced protein) is a 287 amino acid single-pass membrane protein that contains WW-binding motifs and localizes to the cell membrane. Expressed at high levels in prostate, kidney and ovary, PMEPA1/TMEPAI interacts with NEDD4 and may play a role in regulating AR (androgen receptor) levels, specifically in prostate cells. Down regulation of TMEPAI is observed in prostate tumors, suggesting that TMEPAI may exhibit activity as a tumor suppressor. Overexpression of this protein may play a role in multiple types of cancer.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
Q969W9
Host
Mouse
Reactivity
Human
Immunogen
Full-length recombinant human protein was used as the immunogen for the TMEPAI antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
PMEPA1/2698
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the TMEPAI antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This TMEPAI antibody is available for research use only.
Storage Conditions
Store the TMEPAI antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Location
Cell surface, cytoplasm
Image Legend
IHC staining of FFPE human prostate carcinoma with TMEPAI antibody (clone PMEPA1/2698) . HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min and allow to cool before testing.

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