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Active PAD4, Human Recombinant

CAT: 0026-P1720-100Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0026-P1720-100Size:100 µg
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Description
Protein arginine deiminases (PADs) are a family of guanidine-modifying enzymes that catalyze the post-translational modification of target proteins by converting arginine to citrulline. Excessive citrullination of proteins may result in disease states. PAD4 (also known as PADI5) is expressed in neutrophils and in a variety of tissues. PAD4 is known to citrullinate histones, which initiates chromatin decondensation in neutrophils and the subsequent release of neutrophil extracellular traps (NETs), which leads to a lytic form of cell death known as NETosis. The presence of serum PAD4 autoantibodies has been associated with rheumatoid arthritis.
CAS Number
9000-83-3
Shipping Conditions
Gel Pack
Storage Conditions
-80°C
Shelf Life
12 months

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