Anti-ZAP70 (Chronic Lymphocytic Leukemia Marker)(ZAP70/2047), Biotin conjugate
CAT:
37-BNCB2047-500
Size:
500 µL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Anti-ZAP70 (Chronic Lymphocytic Leukemia Marker)(ZAP70/2047), Biotin conjugate
- Description: ZAP70 is a 70 kDa protein tyrosine kinase found in T-cells and natural killer cells. Control of this protein translation is via the IgVH gene. ZAP70 protein is expressed in leukemic cells of approximately 25% of chronic lymphocytic leukemia (CLL) cases as well. Anti-ZAP70 expression is an excellent surrogate marker for the distinction between the Ig-mutated (anti-ZAP70 negative) and Ig-unmutated (anti-ZAP70 positive) CLL subtypes and can identify patient groups with divergent clinical courses. The anti-ZAP70 positive Ig-unmutated CLL cases have been shown to have a poorer prognosis._x000D_ _x000D_ Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors._x000D_ _x000D_
- Synonyms: Selective T cell defect; SRK; STD; Syk-related tyrosine kinase; Tyrosine-protein kinase ZAP-70; TZK; Zeta chain associated protein kinase 70kDa
- CAS Number: 9007-83-4
- UNSPSC: 41116161
- UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
- Gene Name: ZAP70
- Gene ID: 7535
- NCBI Gene ID: 234569
- UniProt: P43403
- Cellular Locus: Cytoplasmic
- Host: Mouse
- Species Reactivity: Human
- Immunogen: Recombinant fragment (around aa 247-382) of human ZAP70 protein (exact sequence is proprietary)
- Target Antigen: ZAP70
- Clonality: Monoclonal
- Isotype: IgG1 κ
- Clone: ZAP70/2047
- Conjugation: Biotin
- Disease: Tumor
- Source: Animal
- Applications: Flow, intracellular (verified) | IF (verified) | IHC, FFPE (verified)
- Validated Applications: FC, IF, IHC, FFPE
- Positive Control: Jurkat cells. Tonsil or lymph node.
- Concentration: 0.1 mg/mL
- Buffer: PBS, 0.1% BSA, 0.05% azide
- Molecular Weight: 70 kDa
- Shipping Conditions: Room temperature
- Storage Conditions: 4°C; Stable at room temperature or 37°C (98°F) for 7 days.
- Shelf Life: 2 years