ZAP70 (Chronic Lymphocytic Leukemia Marker)

ZAP70 (Chronic Lymphocytic Leukemia Marker)

• Gene Name: [ZAP70]
• NCBI Gene ID: 7535
• Reactivity: Human. Others not known
• Storage Conditions: Antibody with azide - store at 2 to 8 degree C.
  Antibody without azide - store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.
• Specificity: ZAP70 is a 70kDa protein tyrosine kinase found in T-cells and natural killer cells. Control of this protein translation is via the IgVH gene.ZAP70 protein is expressed in leukemic cells of approximately 25% of chronic lymphocytic leukemia (CLL) cases as well.Anti-ZAP70 expression is an excellent surrogate marker for the distinction between the Ig-mutated (anti-ZAP70 negative) and Ig-unmutated (anti-ZAP70 positive) CLL subtypes and can identify patient groups with divergent clinical courses. The anti-ZAP70 positive Ig-unmutated CLL cases have been shown to have a poorer prognosis.
• Other Gene Names: [ZAP70; ZAP70; SRK; STD; TZK; STCD; IMD48; ADMIO2; ZAP-70; SRK]
• Short Name: [ZAP70]
• Other Product Names: [tyrosine-protein kinase ZAP-70 isoform 1; Tyrosine-protein kinase ZAP-70; tyrosine-protein kinase ZAP-70; zeta chain of T cell receptor associated protein kinase 70; 70 kDa zeta-chain associated protein; Syk-related tyrosine kinase]
• NCBI GI Number: 31455611
• NCBI Accession Number: NP_001070.2
• NCBI GB Accession Number: NM_001079.3
• Uniprot Accession Number: P43403