ZAP70(Chronic Lymphocytic Leukemia Marker)
CAT:
544-MBS4381685-04
Size:
5x 0.1 mg (With BSA & Azide at 0.2mg/mL)
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
ZAP70(Chronic Lymphocytic Leukemia Marker)
- Gene Name: [ZAP70]
- NCBI Gene ID: 7535
- Reactivity: Human
- Storage Conditions: Antibody with azide: store at 2 to 8 degree C.
Antibody without azide: store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required. - Specificity: ZAP70 is a 70kDa protein tyrosine kinase found in T-cells and natural killer cells. Control of this protein translation is via the IgVH gene.ZAP70 protein is expressed in leukemic cells of approximately 25% of chronic lymphocytic leukemia (CLL) cases as well. Anti-ZAP70 expression is an excellent surrogate marker for the distinction between the Ig-mutated (anti-ZAP70 negative) and Ig-unmutated (anti-ZAP70 positive) CLL subtypes and can identify patient groups with divergent clinical courses. The anti-ZAP70 positive Ig-unmutated CLL cases have been shown to have a poorer prognosis.
- Other Gene Names: [ZAP70; ZAP70; SRK; STD; TZK; STCD; IMD48; ADMIO2; ZAP-70; SRK]
- Short Name: [ZAP70]
- Other Product Names: [tyrosine-protein kinase ZAP-70 isoform 1; Tyrosine-protein kinase ZAP-70; tyrosine-protein kinase ZAP-70; zeta chain of T cell receptor associated protein kinase 70; 70 kDa zeta-chain associated protein; Syk-related tyrosine kinase]
- NCBI GI Number: 31455611
- NCBI Accession Number: NP_001070.2
- NCBI GB Accession Number: NP_001070.2
- Uniprot Accession Number: P43403