Anti-CD137L / 4-1BBL / TNFSF9(CD137L/1547), CF594 conjugate

• Description:

  TNFSF9 / 4-1BBL is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9 / 4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9 / 4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. It has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine is required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

• Synonyms:

  4-1BB ligand; 4-1BBL; CD137L; ILA ligand (TNF related); Ly63l; Tumor necrosis factor ligand 5A (TNLG5A); Tumor necrosis factor ligand superfamily member 9 (TNFSF9)

• UNSPSC:

  41116161

• UNSPSC Description:

  Primary and secondary antibodies for multiple methodology immunostaining detection application

• Gene Name:

  TNFSF9

• Gene ID:

  8744

• NCBI Gene ID:

  1524

• UniProt:

  P41273

• Cellular Locus:

  Plasma membrane

• Host:

  Mouse

• Species Reactivity:

  Human

• Immunogen:

  Recombinant full-length human CD137L protein

• Target Antigen:

  4-1BBL | CD137L | TNFSF9

• Clonality:

  Monoclonal

• Isotype:

  IgG2a κ

• Clone:

  CD137L/1547

• Conjugation:

  CF594

• Source:

  Animal

• Applications:

  Flow (verified) | IHC, FFPE (verified)

• Validated Applications:

  FC, IHC, FFPE

• Positive Control:

  Raji, 293T, HEK293 cells. Kidney.

• Concentration:

  0.1 mg/mL

• Buffer:

  PBS, 0.1% BSA, 0.05% azide

• Molecular Weight:

  27 kDa

• Shipping Conditions:

  Room temperature

• Storage Conditions:

  4°C; Protect from light; Stable at room temperature or 37°C (98°F) for 7 days.

• Shelf Life:

  2 years

• CAS Number:

  9007-83-4