ERD-308
CAT:
804-HY-128600-03
Size:
50 mg
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
ERD-308
- CAS Number: 2320561-35-9
- UNSPSC Description: ERD-308 is a highly potent von Hippel-Lindau-based PROTAC degrader of estrogen receptor (ER) for ER positive breast cancer treatment. ERD-308 induces >95% of ER degradation at concentrations as low as 5 nM in both cell lines (DC50 (concentration causing 50% of protein degradation) of 0.17 nM and 0.43 nM in MCF-7 and T47D ER+ cells, respectively)[1].
- Target Antigen: Estrogen Receptor/ERR; PROTACs
- Type: Reference compound
- Related Pathways: PROTAC;Vitamin D Related/Nuclear Receptor
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/erd-308.html
- Purity: 99.17
- Solubility: DMSO : 50 mg/mL (ultrasonic)
- Smiles: O=C(C1=C(C2=CC=C(O)C=C2)SC3=CC(O)=CC=C13)C4=CC=C(OCCN(CCCCCOCC(N[C@@H](C(C)(C)C)C(N5[C@H](C(N[C@@H](C)C6=CC=C(C7=C(C)N=CS7)C=C6)=O)C[C@@H](O)C5)=O)=O)CC)C=C4
- Molecular Weight: 1004.26
- References & Citations: [1]Hu J, et al. Discovery of ERD-308 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Estrogen Receptor (ER). J Med Chem. 2019 Feb 14;62(3):1420-1442.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, protect from light)
- Clinical Information: No Development Reported