Products for Research Use Only
RegisterLogin

Malabaricone C

CAT: 0804-HY-N8518-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-N8518-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Malabaricone C is an orally active and noncompetitive sphingomyelin synthase (SMS) inhibitor with IC50 values of 3 μM and 1.5 μM for SMS 1 and SMS 2, respectively. Malabaricone C reduces body weight gain, improves glucose tolerance, and decreases lipid accumulation in the liver, showing significant prevention of high fat diet-induced fatty liver in mice. Malabaricone C has anti-inflammatory effects, which is found in the fruits of Myristica cinnamomea King. Malabaricone C is promising for research of obesity and immunological disorders caused due to hyper-activation of T-cells[1][2][3].
CAS Number
63335-25-1
UNSPSC
12352005
Target
Apoptosis; NF-κB; p38 MAPK; Phospholipase
Type
Natural Products
Related Pathways
Apoptosis; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/malabaricone-c.html
Concentration
10mM
Purity
99.46
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=C(O)C=CC=C1O)CCCCCCCCC2=CC=C(O)C(O)=C2
Molecular Formula
C21H26O5
Molecular Weight
358.43
References & Citations
[1]Othman MA, et al. Malabaricone C as Natural Sphingomyelin Synthase Inhibitor against Diet-Induced Obesity and Its Lipid Metabolism in Mice. ACS Med Chem Lett. 2019;10 (8) :1154-1158. Published 2019 Jul 3.|[2]Patwardhan RS, et al. Malabaricone C, a constituent of spice Myristica malabarica, exhibits anti-inflammatory effects via modulation of cellular redox. J Biosci. 2023;48 (2) :9.|[3]Tyagi M, et al. Mechanism of the malabaricone C-induced toxicity to the MCF-7 cell line. Free Radic Res. 2014 Apr;48 (4) :466-77.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

Related Products

CatalogName
HY-N9973-01Malabaricone A
HY-N8517-01Malabaricone B
HY-140336-01C-NH-Boc-C-Bis- (C-PEG1-Boc)
HY-138383CHO-C-PEG2-C-CHO
HY-168132Thalidomide-NH-C-C6H10-C-acid
HY-161974Adamantan-C-amide-PEG2-C-Br
HY-W382140-014′-C-Fluoro-2′-C-methyluridine
HY-178831Azacyclohexane-C-piperazine-C (OCH3) 2
HY-161210Thalidomide-azetidine-C-PIP-C-boc
HY-P11336Oscillamide C

Alternative Products

CatalogName
MBS5765744Malabaricone A
MBS3614263-01Malabaricone C
MBS5765745Malabaricone B
TRC-M213850-100MGMalabaricone E

Popular Products