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Busulfan-d8

CAT: 0804-HY-B0245S-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0245S-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Busulfan-d8 is a deuterium labeled Busulfan. Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent[1][2][3].
CAS Number
116653-28-2
UNSPSC
12352100
Hazard Statement
H301, H310+H330, H350
Target
Apoptosis; DNA Alkylator/Crosslinker
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology
Purity
99.73
Solubility
10 mM in DMSO|DMF : ≥ 16.7mg/mL|DMSO : ≥ 16.7mg/mL
Smiles
CS(=O)(OC([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])OS(C)(=O)=O)=O
Molecular Formula
C6H6D8O6S2
Molecular Weight
254.35
Precautions
H301, H310+H330, H350
References & Citations
[1]Virginia Probin, et al. Busulfan-induced senescence is dependent on ROS production upstream of the MAPK pathway. Free Radic Biol Med. 2007 Jun 15;42 (12) :1858-65.|[2]Mattan Levi, et al. Treosulfan induces distinctive gonadal toxicity compared with busulfan. Oncotarget. 2018 Apr 10;9 (27) :19317-19327.|[3]Janka Reimer, et al. Antineoplastic agent busulfan regulates a network of genes related to coagulation and fibrinolysis. Eur J Clin Pharmacol. 2012 Jun;68 (6) :923-35.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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AR-B02313-01Busulfan-d8
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