Diosbulbin C

Diosbulbin C

• CAS Number: 20086-07-1
• UNSPSC Description: Diosbulbin C is a diterpene lactone component, which can be extracted from traditional Chinese medicine Dioscorea bulbifera L.. Diosbulbin C possesses high anticancer activity in non-small cell lung cancer (NSCLC). Diosbulbin C could induce cell cycle arrest at G0/G1 phase in NSCLC. Diosbulbin C also inhibits the proliferation of NSCLC cells, possibly by downregulating the expression/activation of AKT, DHFR, and TYMS[1][1].
• Target Antigen: Akt; Dihydrofolate reductase (DHFR) ; Endogenous Metabolite
• Type: Natural Products
• Related Pathways: Metabolic Enzyme/Protease;PI3K/Akt/mTOR
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/diosbulbin-c.html
• Smiles: O=C([C@@H]1C[C@H](O)C[C@@]2([H])[C@@]3(C)[C@@](O[C@@H](C4=COC=C4)C3)(C5)C(O[C@]5([H])[C@@]21[H])=O)O
• Molecular Weight: 362.37
• References & Citations: [1]Zhu Z, et al. Diosbulbin C, a novel active ingredient in Dioscorea bulbifera L. extract, inhibits lung cancer cell proliferation by inducing G0/G1 phase cell cycle arrest. BMC Complement Med Ther. 2023 Dec 4;23(1):436.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported