Diosbulbin C

• Description :

  Diosbulbin C is a diterpene lactone component, which can be extracted from traditional Chinese medicine Dioscorea bulbifera L.. Diosbulbin C possesses high anticancer activity in non-small cell lung cancer (NSCLC) . Diosbulbin C could induce cell cycle arrest at G0/G1 phase in NSCLC. Diosbulbin C also inhibits the proliferation of NSCLC cells, possibly by downregulating the expression/activation of AKT, DHFR, and TYMS[1][1].

• CAS Number :

  [20086-07-1]

• UNSPSC :

  12352005

• Target :

  Akt; Dihydrofolate reductase (DHFR) ; Endogenous Metabolite

• Type :

  Natural Products

• Related Pathways :

  Metabolic Enzyme/Protease; PI3K/Akt/mTOR

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/diosbulbin-c.html

• Smiles :

  O=C([C@@H]1C[C@H](O)C[C@@]2([H])[C@@]3(C)[C@@](O[C@@H](C4=COC=C4)C3)(C5)C(O[C@]5([H])[C@@]21[H])=O)O

• Molecular Formula :

  C19H22O7

• Molecular Weight :

  362.37

• References & Citations :

  [1]Zhu Z, et al. Diosbulbin C, a novel active ingredient in Dioscorea bulbifera L. extract, inhibits lung cancer cell proliferation by inducing G0/G1 phase cell cycle arrest. BMC Complement Med Ther. 2023 Dec 4;23 (1) :436.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported