Diosbulbin C

• UNSPSC Description:

  Diosbulbin C is a diterpene lactone component, which can be extracted from traditional Chinese medicine Dioscorea bulbifera L.. Diosbulbin C possesses high anticancer activity in non-small cell lung cancer (NSCLC). Diosbulbin C could induce cell cycle arrest at G0/G1 phase in NSCLC. Diosbulbin C also inhibits the proliferation of NSCLC cells, possibly by downregulating the expression/activation of AKT, DHFR, and TYMS[1][1].

• Target Antigen:

  Akt; Dihydrofolate reductase (DHFR) ; Endogenous Metabolite

• Type:

  Natural Products

• Related Pathways:

  Metabolic Enzyme/Protease;PI3K/Akt/mTOR

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/diosbulbin-c.html

• Smiles:

  O=C([C@@H]1C[C@H](O)C[C@@]2([H])[C@@]3(C)[C@@](O[C@@H](C4=COC=C4)C3)(C5)C(O[C@]5([H])[C@@]21[H])=O)O

• Molecular Weight:

  362.37

• References & Citations:

  [1]Zhu Z, et al. Diosbulbin C, a novel active ingredient in Dioscorea bulbifera L. extract, inhibits lung cancer cell proliferation by inducing G0/G1 phase cell cycle arrest. BMC Complement Med Ther. 2023 Dec 4;23(1):436.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  20086-07-1