Diosbulbin B

• Description:

  Diosbulbin B, a diterpene lactone, is an anticancer agent. Diosbulbin B is an orally active component of Dioscorea. bulbifera L. Diosbulbin B can inhibit cell proliferation, induce G0/G1 phase arrest and apoptosis. Diosbulbin B can induce autophagy and mitochondrial dysfunction. Diosbulbin B can induce liver injury. Diosbulbin B can be used for the research of cancer, such as non-small cell lung cancer (NSCLC) [1][2][3].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Apoptosis; Bcl-2 Family; CDK; MDM-2/p53

• Type:

  Natural Products

• Related Pathways:

  Apoptosis; Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/diosbulbin-b.html

• Purity:

  99.90

• Solubility:

  DMSO : 16 mg/mL (ultrasonic)

• Smiles:

  O=C1[C@]23C[C@H](O1)[C@]4([H])[C@H]5C[C@H](OC5=O)C[C@@]4([H])[C@]2(C)C[C@H](C6=COC=C6)O3

• Molecular Formula:

  C19H20O6

• Molecular Weight:

  344.36

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Zhao JQ, et al. The anti-non-small cell lung cancer effect of Diosbulbin B: Targeting YY1 induced cell cycle arrest and apoptosis. Phytomedicine. 2024 Jul 25;130:155734.|[2]Ma Y, et al. Diosbulbin B-induced liver injury in mice and its mechanism. Hum Exp Toxicol. 2014 Jul;33 (7) :729-36. |[3]Ye J, et al. Diosbulbin B-Induced Mitochondria-Dependent Apoptosis in L-02 Hepatocytes is Regulated by Reactive Oxygen Species-Mediated Autophagy. Front Pharmacol. 2019 Jun 19;10:676.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  [20086-06-0]