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Ro5-3335

CAT: 0804-HY-108470-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-108470-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ro5-3335, a benzodiazepine, acts as an inhibitor of core binding factor (CBF) leukemia. Ro5-3335 is a RUNX1-CBFβ interaction inhibitor that represses RUNX1/CBFB-dependent transactivation[1].
CAS Number
30195-30-3
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
RUNX
Type
Reference compound
Related Pathways
Stem Cell/Wnt; TGF-beta/Smad
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ro5-3335.html
Purity
99.52
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1NC2=CC=C(Cl)C=C2C(C3=CC=CN3)=NC1
Molecular Formula
C13H10ClN3O
Molecular Weight
259.69
Precautions
H302, H315, H319, H335
References & Citations
[1]Cunningham L, et al. Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFβ interaction. Proc Natl Acad Sci U S A. 2012 Sep 4;109 (36) :14592-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RUNX1

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Alternative Products

CatalogName
BUP04213-01Ro5-3335
217258CBF beta-Runx1 Inhibitor II (Ro5-3335)
GTR19260324-01Ro 5-3335
TBI5887-5MGRo 5-3335, RUNX1 inhibitor
256486Ro 5-3335 discontinued. See 217258
3335-100μgAnti-Estrogen Receptorα Antibody (3335) - 100 μg
E2261-01AEMP3 (Epithelial Membrane Protein 3, EMP 3, EMP-3, Hematopoietic Neural Membrane Protein, HNMP 1, HNMP-1, HGNC:3335, Protein YMP, YMP, YMP Protein) discontinued
MBS622887-01EMP3 (Epithelial Membrane Protein 3, EMP 3, EMP-3, Hematopoietic Neural Membrane Protein, HNMP 1, HNMP-1, HGNC:3335, Protein YMP, YMP, YMP Protein)
E2261-01A1EMP3 Blocking Peptide (Epithelial Membrane Protein 3, EMP 3, EMP-3, Hematopoietic Neural Membrane Protein, HNMP 1, HNMP-1, HGNC:3335, Protein YMP, YMP, YMP Protein) discontinued

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