Ro5-3335

• Description:

  Ro5-3335, a benzodiazepine, acts as an inhibitor of core binding factor (CBF) leukemia. Ro5-3335 is a RUNX1-CBFβ interaction inhibitor that represses RUNX1/CBFB-dependent transactivation[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  RUNX

• Type:

  Reference compound

• Related Pathways:

  Stem Cell/Wnt; TGF-beta/Smad

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ro5-3335.html

• Purity:

  99.52

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C1NC2=CC=C(Cl)C=C2C(C3=CC=CN3)=NC1

• Molecular Formula:

  C13H10ClN3O

• Molecular Weight:

  259.69

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Cunningham L, et al. Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFβ interaction. Proc Natl Acad Sci U S A. 2012 Sep 4;109 (36) :14592-7.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  RUNX1

• CAS Number:

  [30195-30-3]