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Azido-PEG2-hydrazide-Boc

CAT: 0804-HY-140816-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-140816-01Size:50 mg
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Description
Azido-PEG2-hydrazide-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG2-hydrazide-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
CAS Number
2100306-56-5
UNSPSC
12352211
Hazard Statement
H302-H315-H319-H335
Target
PROTAC Linkers
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/azido-peg2-hydrazide-boc.html
Purity
97.0
Solubility
10 mM in DMSO
Smiles
O=C(NNC(OC(C)(C)C)=O)CCOCCOCCN=[N+]=[N-]
Molecular Formula
C12H23N5O5
Molecular Weight
317.34
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PEG Linkers

Chemical Information

Azido-PEG2-t-Boc-hydrazide
CAS Number2100306-56-5
PubChem CID129009587
IUPAC Nametert-butyl N-[3-[2-(2-azidoethoxy)ethoxy]propanoylamino]carbamate
Molecular FormulaC12H23N5O5
Molecular Weight317.34
XLogP1
Topological Polar Surface Area100
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count11
Heavy Atom Count22
Formal Charge0
Complexity390
SMILES
CC(C)(C)OC(=O)NNC(=O)CCOCCOCCN=[N+]=[N-]
InChI
InChI=1S/C12H23N5O5/c1-12(2,3)22-11(19)16-15-10(18)4-6-20-8-9-21-7-5-14-17-13/h4-9H2,1-3H3,(H,15,18)(H,16,19)
InChIKey
JYNHRXFEKXQQDG-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Azido-PEG2-t-Boc-hydrazide
CAS: 2100306-56-5
CID: 129009587
Formula: C12H23N5O5
MW: 317.34
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight317.34
XLogP31
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count11
Exact Mass317.16991885
Monoisotopic Mass317.16991885
Topological Polar Surface Area100 Ų
Heavy Atom Count22
Formal Charge0
Complexity390
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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