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Cisapride (Standard)

CAT: 0804-HY-14149R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14149R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cisapride (Standard) is the analytical standard of Cisapride. This product is intended for research and analytical applications. Cisapride (R 51619) is an orally active 5-HT4 receptor agonist with an EC50 value of 140 nM. Cisapride is a hERG blocker with an IC50 value of 9.4 nM. Cisapride is a gastroprokinetic agent that stimulates gastrointestinal motor activity[1][2][3][4].
CAS Number
81098-60-4
Product Name Alternative
R 51619 (Standard) ; (±) -Cisaprid (Standard)
UNSPSC
12352005
Target
5-HT Receptor; Potassium Channel; Reference Standards
Type
Reference Standards
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling; Others
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cisapride-standard.html
Smiles
ClC1=C(N)C=C(OC)C(C(N[C@H]2[C@@H](OC)CN(CCCOC3=CC=C(F)C=C3)CC2)=O)=C1
Molecular Formula
C23H29ClFN3O4
Molecular Weight
465.95
References & Citations
[1]Toga, T., Y. Kohmura, and R. Kawatsu, The 5-HT (4) agonists cisapride, mosapride, and CJ-033466, a Novel potent compound, exhibit different human ether-a-go-go-related gene (hERG) -blocking activities. J Pharmacol Sci, 2007. 105 (2) : p. 207-10.|[2]Sung, K.W. and S.J. Hahn, Effect of mosapride on Kv4.3 potassium channels expressed in CHO cells. Naunyn Schmiedebergs Arch Pharmacol, 2013. 386 (10) : p. 905-16.|[3]Mine, Y, et al. Comparison of effect of mosapride citrate and existing 5-HT4 receptor agonists on gastrointestinal motility in vivo and in vitro. J Pharmacol Exp Ther, 1997. 283 (3) : p. 1000-8.|[4]Motavallian, A, et al., Does Cisapride, as a 5HT (4) Receptor Agonist, Aggravate the Severity of TNBS-Induced Colitis in Rat. Gastroenterol Res Pract, 2012. 2012: p. 362536.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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