Cisapride

• Description :

  Cisapride (R 51619) is an orally active 5-HT4 receptor agonist with an EC50 value of 140 nM. Cisapride is a hERG blocker with an IC50 value of 9.4 nM. Cisapride is a gastroprokinetic agent that stimulates gastrointestinal motor activity[1][2][3][4].

• Product Name Alternative :

  R 51619; (±) -Cisaprid

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H320

• Target :

  5-HT Receptor; Potassium Channel

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/Cisapride.html

• Purity :

  99.87

• Solubility :

  DMSO : 100 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

• Smiles :

  ClC1=C(N)C=C(OC)C(C(N[C@H]2[C@@H](OC)CN(CCCOC3=CC=C(F)C=C3)CC2)=O)=C1

• Molecular Formula :

  C23H29ClFN3O4

• Molecular Weight :

  465.95

• Precautions :

  H315, H319, H320

• References & Citations :

  [1]Toga, T., Y. Kohmura, and R. Kawatsu, The 5-HT (4) agonists cisapride, mosapride, and CJ-033466, a Novel potent compound, exhibit different human ether-a-go-go-related gene (hERG) -blocking activities. J Pharmacol Sci, 2007. 105 (2) : p. 207-10.|[2]Sung, K.W. and S.J. Hahn, Effect of mosapride on Kv4.3 potassium channels expressed in CHO cells. Naunyn Schmiedebergs Arch Pharmacol, 2013. 386 (10) : p. 905-16.|[3]Mine, Y, et al. Comparison of effect of mosapride citrate and existing 5-HT4 receptor agonists on gastrointestinal motility in vivo and in vitro. J Pharmacol Exp Ther, 1997. 283 (3) : p. 1000-8.|[4]Motavallian, A, et al., Does Cisapride, as a 5HT (4) Receptor Agonist, Aggravate the Severity of TNBS-Induced Colitis in Rat. Gastroenterol Res Pract, 2012. 2012: p. 362536.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  Apolipoprotein D

• CAS Number :

  [81098-60-4]