Cisapride (monohydrate)

CAT: 0804-HY-14149ASize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-14149ASize:1 Each
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Description
Cisapride monohydrate is an orally and potent 5-HT4 receptor agonist and hERG inhibitor. Cisapride monohydrate is an prokinetic agent which facilitates or restores motility throughout the length of the gastrointestinal tract. Cisapride monohydrate stimulates gastrointestinal motor activity through an indirect mechanism involving the release of acetylcholine mediated by postganglionic nerve endings in the myenteric plexus of the gut[1][2].
CAS Number
[260779-88-2]
Product Name Alternative
R 51619 (monohydrate) ; (±) -Cisaprid (monohydrate)
UNSPSC
12352005
Hazard Statement
H318
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cisapride-monohydrate.html
Solubility
10 mM in DMSO
Smiles
ClC1=C(N)C=C(OC)C(C(N[C@H]2[C@@H](OC)CN(CCCOC3=CC=C(F)C=C3)CC2)=O)=C1.O
Molecular Formula
C23H31ClFN3O5
Molecular Weight
483.96
Precautions
P280-P305+P351+P338
References & Citations
[1]Wiseman, L.R., Faulds, D. Cisapride. Drugs 47, 116–152 (1994) .|[2]Toga T, et al. The 5-HT (4) agonists cisapride, mosapride, and CJ-033466, a Novel potent compound, exhibit different human ether-a-go-go-related gene (hERG) -blocking activities. J Pharmacol Sci. 2007 Oct;105 (2) :207-10.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Apolipoprotein D

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