Cisapride (monohydrate)

• Description :

  Cisapride monohydrate is an orally and potent 5-HT4 receptor agonist and hERG inhibitor. Cisapride monohydrate is an prokinetic agent which facilitates or restores motility throughout the length of the gastrointestinal tract. Cisapride monohydrate stimulates gastrointestinal motor activity through an indirect mechanism involving the release of acetylcholine mediated by postganglionic nerve endings in the myenteric plexus of the gut[1][2].

• Product Name Alternative :

  R 51619 (monohydrate) ; (±) -Cisaprid (monohydrate)

• UNSPSC :

  12352005

• Hazard Statement :

  H318

• Target :

  5-HT Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/cisapride-monohydrate.html

• Solubility :

  10 mM in DMSO

• Smiles :

  ClC1=C(N)C=C(OC)C(C(N[C@H]2[C@@H](OC)CN(CCCOC3=CC=C(F)C=C3)CC2)=O)=C1.O

• Molecular Formula :

  C23H31ClFN3O5

• Molecular Weight :

  483.96

• Precautions :

  P280-P305+P351+P338

• References & Citations :

  [1]Wiseman, L.R., Faulds, D. Cisapride. Drugs 47, 116–152 (1994) .|[2]Toga T, et al. The 5-HT (4) agonists cisapride, mosapride, and CJ-033466, a Novel potent compound, exhibit different human ether-a-go-go-related gene (hERG) -blocking activities. J Pharmacol Sci. 2007 Oct;105 (2) :207-10.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  Apolipoprotein D

• CAS Number :

  [260779-88-2]