UCM-1306
CAT:
804-HY-148867-05
Size:
50 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
UCM-1306
- CAS Number: 2258608-78-3
- UNSPSC Description: UCM-1306 is a potent and orally active human dopamine D1 receptor allosteric modulator (PAM). UCM-1306 increases the endogenous dopamine (DA) maximal effect both in human and mouse D1 receptors. UCM-1306 is not only for improving motor symptoms but also for addressing the key comorbid cognitive impairment associated with long-term Parkinson’s disease (PD)[1].
- Target Antigen: Dopamine Receptor
- Type: Reference compound
- Related Pathways: GPCR/G Protein;Neuronal Signaling
- Applications: Neuroscience-Neurodegeneration
- Field of Research: Neurological Disease
- Assay Protocol: https://www.medchemexpress.com/ucm-1306.html
- Solubility: DMSO : 50 mg/mL (ultrasonic)
- Smiles: O=S(C1=CC=C(C2=C(OCF)C=CC=C2)C=C1)(C)=N
- Molecular Weight: 279.33
- References & Citations: [1]García-Cárceles J, et, al. 2-(Fluoromethoxy)-4'-(S-methanesulfonimidoyl)-1,1'-biphenyl (UCM-1306), an Orally Bioavailable Positive Allosteric Modulator of the Human Dopamine D1 Receptor for Parkinson's Disease. J Med Chem. 2022 Sep 22;65(18):12256-12272.
- Shipping Conditions: Blue Ice
- Clinical Information: No Development Reported