CATB (Cleaved-Leu80) rabbit pAb

• Background:

  Catalytic activity:Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L) . In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides., function:Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis., similarity:Belongs to the peptidase C1 family., subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV., subunit:Dimer of a heavy chain and a light chain cross-linked by a disulfide bond.

• Description:

  Catalytic activity: Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides. function: Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis. similarity: Belongs to the peptidase C1 family. subcellular location: Identified by mass spectrometry in melanosome fractions from stage I to stage IV. subunit: Dimer of a heavy chain and a light chain cross-linked by a disulfide bond.

• UniProt:

  P07858

• Swiss Prot:

  P07858

• Reactivity:

  Human; Rat; Mouse

• Immunogen:

  Synthesized peptide derived from human CATB (Cleaved-Leu80)

• Clonality:

  Polyclonal

• Source:

  Rabbit

• Applications:

  WB; ELISA

• Concentration:

  1 mg/ml

• Dilution:

  WB 1:1000-2000 ELISA 1:5000-20000

• Molecular Weight:

  28 37kD

• Storage Conditions:

  -20°C/1 year

• Observed Molecular Weight:

  28 37kD

• Fragment:

  IgG

• Subcellular Location:

  Lysosome . Melanosome . Secreted, extracellular space . Apical cell membrane ; Peripheral membrane protein ; Extracellular side . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065) . Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells (By similarity) . .

• Other Product Names:

  Cathepsin B (EC 3.4.22.1; APP secretase; APPS; Cathepsin B1) [Cleaved into: Cathepsin B light chain; Cathepsin B heavy chain]

• Gene ID (Human):

  1508