CATB (Cleaved-Asn126) rabbit pAb

CATB (Cleaved-Asn126) rabbit pAb

• Description: Catalytic activity: Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides. function: Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis. similarity: Belongs to the peptidase C1 family. subcellular location: Identified by mass spectrometry in melanosome fractions from stage I to stage IV. subunit: Dimer of a heavy chain and a light chain cross-linked by a disulfide bond.
• Synonyms: Cathepsin B (EC 3.4.22.1;APP secretase;APPS;Cathepsin B1) [Cleaved into: Cathepsin B light chain; Cathepsin B heavy chain]
• Gene ID: 1508
• UniProt: P07858
• Cellular Locus: Lysosome. Melanosome. Secreted, extracellular space. Apical cell membrane ; Peripheral membrane protein ; Extracellular side. Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells (By similarity)..
• Host: Rabbit
• Species Reactivity: Human, Rat, Mouse,
• Immunogen: Synthesized peptide derived from human CATB (Cleaved-Asn126)
• Clonality: Polyclonal
• Validated Applications: WB, ELISA
• Stability: 1 year
• Concentration: 1 mg/mL
• Dilution: WB 1:1000-2000 ELISA 1:5000-20000
• Molecular Weight: 15 37kD
• Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.