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TPh A

CAT: 0804-HY-14454-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-14454-02Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TPh A (Triphenyl Compound A) is a potent inhibitor of the nuclear protein pirin and binds specifically to pirin with a Ki of 0.6 uM. TPh A disrupts the formation of the bcl3–pirin complex. TPh A can be used as a novel small molecule tool to regulate pirin in cells[1].
CAS Number
21306-65-0
Product Name Alternative
Triphenyl Compound A
UNSPSC
12352005
Target
Others
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tph-a.html
Purity
99.81
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=[S](/N=[S](C(C=C1)=CC=C1OCC2=CC=CC=C2)\C)(C(C=C3)=CC=C3C)=O
Molecular Formula
C21H21NO3S2
Molecular Weight
399.53
References & Citations
[1]Isao Miyazaki, et al. A Small-Molecule Inhibitor Shows That Pirin Regulates Migration of Melanoma Cells. Nat Chem Biol. 2010 Sep;6 (9) :667-73.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

4-methyl-N-[methyl-(4-phenylmethoxyphenyl)-lambda4-sulfanylidene]benzenesulfonamide
CAS Number21306-65-0
PubChem CID2802868
IUPAC Name4-methyl-N-[methyl-(4-phenylmethoxyphenyl)-lambda4-sulfanylidene]benzenesulfonamide
Molecular FormulaC21H21NO3S2
Molecular Weight399.5
XLogP5.9
Topological Polar Surface Area83.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Heavy Atom Count27
Formal Charge0
Complexity577
SMILES
CC1=CC=C(C=C1)S(=O)(=O)N=S(C)C2=CC=C(C=C2)OCC3=CC=CC=C3
InChI
InChI=1S/C21H21NO3S2/c1-17-8-14-21(15-9-17)27(23,24)22-26(2)20-12-10-19(11-13-20)25-16-18-6-4-3-5-7-18/h3-15H,16H2,1-2H3
InChIKey
IMUPOWQOXOCVBN-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 4-methyl-N-[methyl-(4-phenylmethoxyphenyl)-lambda4-sulfanylidene]benzenesulfonamide
CAS: 21306-65-0
CID: 2802868
Formula: C21H21NO3S2
MW: 399.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight399.5
XLogP35.9
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass399.09628588
Monoisotopic Mass399.09628588
Topological Polar Surface Area83.3 Ų
Heavy Atom Count27
Formal Charge0
Complexity577
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count1
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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