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TPH1-IN-1

CAT: 0804-HY-156093Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-156093Size:1 Each
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Description
TPH1-IN-1 (compound 40) is a xanthine derivative and an inhibitor of tryptophan hydroxylase TPH1 (IC50: 110.1 nM) . TPH1-IN-1 has good in vitro activity and liver microsome stability, and effectively inhibits adipocyte differentiation of T3-L1 cells[1].
CAS Number
3040015-86-6
UNSPSC
12352005
Target
Tryptophan Hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/tph1-in-1.html
Solubility
10 mM in DMSO
Smiles
OC1=CC=C(C(CN2C(C(NC(N3CC)=O)=O)=C3N=C2CC4=CN5C(SC=C5)=N4)=O)C=C1
Molecular Formula
C21H18N6O4S
Molecular Weight
450.47
References & Citations
[1]Yoon J, et al. Synthesis and biological evaluation of xanthine derivatives with phenacyl group as tryptophan hydroxylase 1 (TPH1) inhibitors for obesity and fatty liver disease. Bioorg Med Chem Lett. 2023 Oct 1;94:129461.. .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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