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Cyclapolin 9

CAT: 0804-HY-15159-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-15159-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cyclapolin 9 is a potent, selective and ATP-competitive polo-like kinase 1 (PLK1) inhibitor with an IC50 of 500 nM. Cyclapolin 9 is inactive against other kinases[1][2].
CAS Number
[40533-25-3]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Polo-like Kinase (PLK)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cyclapolin-9.html
Purity
98.09
Solubility
DMSO : 20 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
O=C(C1=[N+]([O-])C2=CC(C(F)(F)F)=CC([N+]([O-])=O)=C2S1)N
Molecular Formula
C9H4F3N3O4S
Molecular Weight
307.21
Precautions
H315, H319, H335
References & Citations
[1]Martin Hennenberg, et al. Inhibition of Prostate Smooth Muscle Contraction by Inhibitors of Polo-Like Kinases. Front Physiol. 2018 Jun 15;9:734.|[2]Campbell McInnes, et al. Inhibitors of Polo-like kinase reveal roles in spindle-pole maintenance. Nat Chem Biol. 2006 Nov;2 (11) :608-17.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PLK1

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