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CD141 Antibody / Thrombomodulin

CAT: 0013-GTR18317012-01Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18317012-01Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
It recognizes a protein of 75kDa, identified as Thrombomodulin, or CD141. Thrombomodulin is a transmembrane glycoprotein with natural anticoagulant properties. It is normally expressed by a restricted number of cells, such as endothelial and mesothelial cells. In addition, synovial lining and syncytio-trophoblasts of placenta also express thrombomodulin. This protein is present in almost all of benign vascular tumors and majority of malignant vascular tumors (Kaposi s sarcoma, angiosarcoma, and epithelioid hemangioendothelioma) . Hence, anti-thrombomodulin serves as a sensitive marker for lymphatic endothelial cells and their tumors. Recently, thrombomodulin antibody has been used for mesothelial cells and malignant mesotheliomas.
UniProt
P07204
Reactivity
Human
Immunogen
Recombinant full-length human protein was used as the immunogen for the CD141 antibody.
Clonality
Recombinant
Clone
THBD/8188R
Conjugation
Unconjugated
Field of Research
Cardiovascular Research; Immunology & Inflammation
Purification
Protein A/G affinity
Dilution
Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the CD141 antibody should be determined by the researcher.
Tested Applications
IHC-P
Host or Source
Rabbit
Preservative
0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin, 0.05% sodium azide
Isotype
Rabbit IgG, kappa

UniProtKB · P07204

Thrombomodulin

TRBM_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P07204
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
THBD
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
TM
EC number
—
Processing
Precursor
Secondary accessions
Q8IV29, Q9UC32
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Biological process

Blood coagulationHemostasis

Disease

Disease variantHemolytic uremic syndromeThrombophilia

PTM

Disulfide bondGlycoproteinHydroxylationProteoglycan

Domain

EGF-like domainRepeatSignalTransmembraneTransmembrane helix

Cellular component

Membrane

Molecular function

Receptor

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