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Thrombomodulin Antibody / CD141

CAT: 0013-GTR18081732-01Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18081732-01Size:20 µg
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Description
It recognizes a protein of 75kDa, identified as Thrombomodulin. Thrombomodulin is a transmembrane glycoprotein with natural anticoagulant properties. It is normally expressed by a restricted number of cells, such as endothelial and mesothelial cells. In addition, synovial lining and syncytio-trophoblasts of placenta also express thrombomodulin. This protein is present in almost all of benign vascular tumors and majority of malignant vascular tumors (Kaposi s sarcoma, angiosarcoma, and epithelioid hemangioendothelioma) . Hence, anti-thrombomodulin serves as a sensitive marker for lymphatic endothelial cells and their tumors. Recently, thrombomodulin antibody has been used for mesothelial cells and malignant mesotheliomas.
UniProt
P07204
Reactivity
Human
Immunogen
Human recombinant partial protein corresponding to amino acids 69-194 was used as the immunogen for this Thrombomodulin antibody.
Clonality
Monoclonal
Clone
THBD/1782
Conjugation
Unconjugated
Field of Research
Cardiovascular Research; Immunology & Inflammation
Purification
Protein G affinity chromatography
Dilution
ELISA: 2-4ug/ml (order BSA/azide-free format), Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the Thrombomodulin antibody to be titered up or down for optimal performance.
Tested Applications
ELISA, IHC-P
Host or Source
Mouse
Preservative
0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin and 0.05% sodium azide
Isotype
Mouse IgG2a, kappa

UniProtKB · P07204

Thrombomodulin

TRBM_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P07204
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
THBD
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
TM
EC number
—
Processing
Precursor
Secondary accessions
Q8IV29, Q9UC32
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Biological process

Blood coagulationHemostasis

Disease

Disease variantHemolytic uremic syndromeThrombophilia

PTM

Disulfide bondGlycoproteinHydroxylationProteoglycan

Domain

EGF-like domainRepeatSignalTransmembraneTransmembrane helix

Cellular component

Membrane

Molecular function

Receptor

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