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FPT

CAT: 0804-HY-160887-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-160887-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FPT, a 2-Aminotetralin, is an efficacious partial agonist at 5-HT1AR, a full agonist at 5-HT1BR and 5-HT1DR with EC50s of 39.3 nM, 1.2 nM, 0.5 nM, respectively. FPT is a weak agonist at 5-HT7R. FPT shows in vivo efficacy as an antiepileptic in Fmr1 knockout mice and has anxiolytic-like and prosocial effects in Fmr1 knockout mice and other mouse models[1].
CAS Number
2048491-06-9
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/fpt.html
Purity
98.06
Solubility
DMSO : 66.67 mg/mL (ultrasonic)
Smiles
FC1=C(C=CC=C1)C2=C3C(C[C@H](CC3)N(C)C)=CC=C2
Molecular Formula
C18H20FN
Molecular Weight
269.36
References & Citations
[1]Tanishka S Saraf, et al. FPT, a 2-Aminotetralin, Is a Potent Serotonin 5-HT1A, 5-HT1B, and 5-HT1D Receptor Agonist That Modulates Cortical Electroencephalogram Activity in Adult Fmr1 Knockout Mice. ACS Chem Neurosci. 2022 Dec 21;13 (24) :3629-3640.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor;5-HT7 Receptor; mLAG-3; MUC3

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