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FPTQ

CAT: 0804-HY-100382-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100382-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FPTQ is potent mGluR1 antagonist with IC50 values of 6 nM and 1.4 nM for human and mouse mGluR1 respectively[1]. FPTQ has anti-oxidant and anti-inflammatory effects in vitro and in vivo[2].
CAS Number
864863-72-9
UNSPSC
12352005
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/FPTQ.html
Purity
99.92
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
FC(N=CC=C1)=C1N2N=NC(C3=CC4=C(C=C3)N=CC=C4)=C2C
Molecular Formula
C17H12FN5
Molecular Weight
305.31
References & Citations
[1]Fujinaga M et al. Synthesis and evaluation of 6-[1- (2-[ (18) F]fluoro-3-pyridyl) -5-methyl-1H-1,2,3-triazol-4-yl]quinoline for positron emission tomography imaging of the metabotropic glutamate receptor type 1 in brain. Bioorg Med Chem, 2011 Jan 1, 19 (1) :102-10.|[2]Geum Ran Kim, et al. Anti-inflammatory effect of a novel synthetic compound 1- ((4-fluorophenyl) thio) isoquinoline in RAW264.7 macrophages and a zebrafish model. Fish Shellfish Immunol. 2019 Apr;87:395-400.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR1

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