Voxvoganan (trihydrochloride)

Voxvoganan (trihydrochloride)

• UNSPSC Description: Voxvoganan (LTX-109) trihydrochloride, a topical antimicrobial, is highly effective against S. aureus with a MIC range of 2 to 4 μg/mL. Voxvoganan trihydrochloride can be used for the research of bacterial skin infections, fungal infections and nasal decolonisation of MRSA[1][2].
• Target Antigen: Bacterial; Fungal
• Type: Reference compound
• Related Pathways: Anti-infection
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/voxvoganan-trihydrochloride.html
• Purity: 98.13
• Solubility: DMSO : 140 mg/mL (ultrasonic)
• Smiles: O=C([C@H](CCCNC(N)=N)N)N[C@H](C(N[C@H](C(NCCC1=CC=CC=C1)=O)CCCNC(N)=N)=O)CC2=C(NC3=C2C=C(C=C3C(C)(C)C)C(C)(C)C)C(C)(C)C.[H]Cl.[H]Cl.[H]Cl
• Molecular Weight: 897.46
• References & Citations: [1]Johan Isaksson, et al. A synthetic antimicrobial peptidomimetic (LTX 109): stereochemical impact on membrane disruption. J Med Chem. 2011 Aug 25;54(16):5786-95.|[2]Louis D Saravolatz, et al. In vitro activities of LTX-109, a synthetic antimicrobial peptide, against methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, daptomycin-nonsusceptible, and linezolid-nonsusceptible Staphylococcus aureus. Antimicrob Agents Chemother. 2012 Aug;56(8):4478-82.|[3]L D Saravolatz, et al. Postantibiotic effect and postantibiotic sub-MIC effect of LTX-109 and mupirocin on Staphylococcus aureus blood isolates. Lett Appl Microbiol. 2017 Nov;65(5):410-413.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, stored under nitrogen)
• Clinical Information: Phase 2