MS31 (trihydrochloride)

MS31 (trihydrochloride)

• CAS Number: 2748239-18-9
• UNSPSC Description: MS31 trihydrochloride is a potent, highly affinity and selective fragment-like methyllysine reader protein spindlin 1 (SPIN1) inhibitor. MS31 trihydrochloride potently inhibits the interactions between SPIN1 and H3K4me3 (IC50=77 nM, AlphaLISA; 243 nM, FP). MS31 trihydrochloride selectively binds Tudor domain II of SPIN1 (Kd=91 nM). MS31 trihydrochloride potently inhibits binding of trimethyllysine-containing peptides to SPIN1, and is not toxic to nontumorigenic cells[1].
• Target Antigen: Epigenetic Reader Domain
• Type: Reference compound
• Related Pathways: Epigenetics
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/ms31-trihydrochloride.html
• Purity: 98.0
• Solubility: DMSO : 62.5 mg/mL (ultrasonic)
• Smiles: NCC1=CC(CN)=C(OC)C(OCCCN2CC(C=CC=C3)=C3C2)=C1.[H]Cl.[H]Cl.[H]Cl
• Molecular Weight: 450.83
• References & Citations: [1]Xiong Y, et al. Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1(SPIN1). J Med Chem. 2019 Jul 24.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported