PD-1/PD-L1-IN-9 (hydrochloride)
CAT:
804-HY-132192A-02
Size:
10 mM / 1 mL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
PD-1/PD-L1-IN-9 (hydrochloride)
- UNSPSC Description: PD-1/PD-L1-IN-9 hydrochloride is a potent and orally active inhibitor of PD-1/PD-L1 interaction, with an IC50 of 3.8 nM. PD-1/PD-L1-IN-9 hydrochloride can enhance the killing activity of tumor cells by immune cells. PD-1/PD-L1-IN-9 hydrochloride also exhibits significant in vivo antitumor activity in a CT26 mouse model[1].
- Target Antigen: PD-1/PD-L1
- Type: Reference compound
- Related Pathways: Immunology/Inflammation
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/pd-1-pd-l1-in-9-hydrochloride.html
- Purity: 99.26
- Solubility: DMSO : 125 mg/mL (ultrasonic)
- Smiles: CC1=C(C=CC=C1C2=CC=CC=C2)C3=NC(OC)=C(C=C3)CNCCO.[H]Cl
- Molecular Weight: 384.90
- References & Citations: [1]Wang T, et, al. Novel Biphenyl Pyridines as Potent Small-Molecule Inhibitors Targeting the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction. J Med Chem. 2021 May 30.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
- Clinical Information: No Development Reported