Recombinant GRK5 Protein

• Description:

  Recombinant GRK5 Protein_x000D_ Catalog number: B2017521_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Amount: 20 µg_x000D_ Molecular Weight or Concentration: 68.8 kDa_x000D_ Supplied as: Solution_x000D_ Applications: a molecular tool for various biochemical applications_x000D_ Storage: -80°C_x000D_ Keywords: G-protein Receptor Kinase 5_x000D_ Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Pronin AN, Benovic JL. Regulation of the G protein-coupled receptor kinase GRK5 by protein kinase C J Biol Chem. 1997 Feb 7;272(6):3806-12._x000D_ 2: Komolov KE, Bhardwaj A, Benovic JL. Atomic Structure of GRK5 Reveals Distinct Structural Features Novel for G Protein-coupled Receptor Kinases J Biol Chem. 2015 Aug 21;290(34):20629-20647._x000D_ 3: Kunapuli P, Benovic JL. Cloning and expression of GRK5: a member of the G protein-coupled receptor kinase family Proc Natl Acad Sci U S A. 1993 Jun 15;90(12):5588-92._x000D_ 4: Komolov KE, Sulon SM, Bhardwaj A, van Keulen SC, Duc NM, Laurinavichyute DK, Lou HJ, Turk BE, Chung KY, Dror RO, Benovic JL. Structure of a GRK5-Calmodulin Complex Reveals Molecular Mechanism of GRK Activation and Substrate Targeting Mol Cell. 2021 Jan 21;81(2):323-339.e11._x000D_ 5: Pfleger J, Gresham K, Koch WJ. G protein-coupled receptor kinases as therapeutic targets in the heart Nat Rev Cardiol. 2019 Oct;16(10):612-622._x000D_ 6: Hullmann JE, Grisanti LA, Makarewich CA, Gao E, Gold JI, Chuprun JK, Tilley DG, Houser SR, Koch WJ. GRK5-mediated exacerbation of pathological cardiac hypertrophy involves facilitation of nuclear NFAT activity Circ Res. 2014 Dec 5;115(12):976-85._x000D_ 7: Kanaide M, Uezono Y, Matsumoto M, Hojo M, Ando Y, Sudo Y, Sumikawa K, Taniyama K. Desensitization of GABA(B) receptor signaling by formation of protein complexes of GABA(B2) subunit with GRK4 or GRK5 J Cell Physiol. 2007 Jan;210(1):237-45._x000D_ 8: Hu LA, Chen W, Premont RT, Cong M, Lefkowitz RJ. G protein-coupled receptor kinase 5 regulates beta 1-adrenergic receptor association with PSD-95 J Biol Chem. 2002 Jan 11;277(2):1607-13._x000D_ 9: Beyett TS, Chen Q, Labudde EJ, Krampen J, Sharma PV, Tesmer JJG. Characterization of a hyperphosphorylated variant of G protein-coupled receptor kinase 5 expressed in E. coli Protein Expr Purif. 2020 Apr;168:105547._x000D_ 10: Kunapuli P, Onorato JJ, Hosey MM, Benovic JL. Expression, purification, and characterization of the G protein-coupled receptor kinase GRK5 J Biol Chem. 1994 Jan 14;269(2):1099-105._x000D_ _x000D_ Products Related to Recombinant GRK5 Protein can be found at Proteins

• Short Description:

  Catalog Number: B2017521 (20 µg)_x000D_ Recombinant GRK5 protein is produced using genetic engineering techniques. GRK5 is an enzyme that regulates G protein-coupled receptors in cells. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request._x000D_ _x000D_

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height :

  0.5

• CAS Number:

  9000-83-3