Human GRK5 Active

CAT: 0952-B2013985Size: 10 µgDry Ice: NoHazardous: No
CAT#:0952-B2013985Size:10 µg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Human GRK5 Active_x000D_ Catalog number: B2013985_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Amount: 10 µg_x000D_ Molecular Weight or Concentration: 95 kDa_x000D_ Supplied as: Solution_x000D_ Applications: molecular tool for various biochemical applications_x000D_ Storage: ‚àí20¬∞C_x000D_ Keywords: GRK5, active, GST tagged human_x000D_ Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MŒ©-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Eguchi A, Coleman R, Gresham K, Gao E, Ibetti J, Chuprun JK, Koch WJ. GRK5 is a regulator of fibroblast activation and cardiac fibrosis Proc Natl Acad Sci U S A. 2021 Feb 2;118(5):e2012854118._x000D_ 2: Zhang Y, Zhang J, Wang J, Chen H, Ouyang L, Wang Y. Targeting GRK2 and GRK5 for treating chronic degenerative diseases: Advances and future perspectives Eur J Med Chem. 2022 Dec 5;243:114668._x000D_ 3: Pfleger J, Gresham K, Koch WJ. G protein-coupled receptor kinases astherapeutic targets in the heart Nat Rev Cardiol. 2019 Oct;16(10):612-622._x000D_ 4: Zhao TL, Gan XX, Bao Y, Wang WP, Liu B, Wang LH. GRK5 promotes tumor progression in renal cell carcinoma Neoplasma. 2019 Feb 6;66(2):261-270._x000D_ 5: Sueishi T, Akasaki Y, Goto N, Kurakazu I, Toya M, Kuwahara M, Uchida T, Hayashida M, Tsushima H, Bekki H, Lotz MK, Nakashima Y. GRK5 Inhibition Attenuates Cartilage Degradation via Decreased NF-B Signaling Arthritis Rheumatol. 2020 Apr;72(4):620-631._x000D_ 6: Hendrickx JO, van Gastel J, Leysen H, Santos-Otte P, Premont RT, Martin B, Maudsley S. GRK5 - A Functional Bridge Between Cardiovascular and Neurodegenerative Disorders Front Pharmacol. 2018 Dec 17;9:1484._x000D_ 7: Zhao J, Li X, Chen X, Cai Y, Wang Y, Sun W, Mai H, Yang J, Fan W, Tang P, Ou M, Zhang Y, Huang X, Zhao B, Cui L. GRK5 influences the phosphorylation of tau via GSK3_ and contributes to Alzheimer's disease J Cell Physiol. 2019 Jul;234(7):10411-10420._x000D_ 8: Pollard CM, Suster MS, Cora N, Carbone AM, Lymperopoulos A. GRK5 is an essential co-repressor of the cardiac mineralocorticoid receptor and is selectively induced by finerenone World J Cardiol. 2022 Apr 26;14(4):220-230._x000D_ 9: Fassbender P, Klenke S, Omer S, Komanek T, Ochsenfarth C, Frey UH, Peters J. Polymorphic Variants in the GRK5 Gene Promoter Are Associated With Diastolic Dysfunction in Coronary Artery Bypass Graft Surgery Patients Anesth Analg. 2022 Apr 1;134(4):858-868._x000D_ 10: Marzano F, Liccardo D, Elia A, Mucio I, de Lucia C, Lucchese AM, Gao E, Ferrara N, Rapacciuolo A, Paolocci N, Rengo G, Koch WJ, Cannavo A. Genetic Catalytic Inactivation of GRK5 Impairs Cardiac Function in Mice Via Dysregulated P53 Levels JACC Basic Transl Sci. 2022 Mar 9;7(4):366-380. _x000D_ _x000D_ Products Related to Human GRK5 Active can be found at Proteins
Short Description
Catalog Number: B2013985 (10 µg)
Weight
0.15
Length
2
Width
0.5
Height
0.5

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