INO-1001 (mesylate)
CAT:
804-HY-15045A
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
INO-1001 (mesylate)
- CAS Number: 501364-91-6
- UNSPSC Description: INO-1001 mesylate is a potent and selective poly (ADP-ribose) polymerase (PARP) inhibitor. INO-1001 mesylate is a potent enhancer of radiation sensitivity and enhances radiation-induced cell killing by interfering with DNA repair mechanisms, resulting in necrotic cell death[1]. INO-1001 mesylate has anti-tumor effects[2].
- Target Antigen: PARP
- Type: Reference compound
- Related Pathways: Cell Cycle/DNA Damage;Epigenetics
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/ino-1001-mesylate.html
- Smiles: O=S(O)(C)=O.O=C1NC2=C(C3=CC=CC=C31)CC4=C2C=CC(S(NCCCN5CCOCC5)(=O)=O)=C4
- Molecular Weight: 535.63
- References & Citations: [1]Brock WA, et al. Radiosensitization of human and rodent cell lines by INO-1001, a novel inhibitor of poly(ADP-ribose) polymerase. Cancer Lett. 2004 Mar 18;205(2):155-60.|[2]Mason KA, et al. INO-1001, a novel inhibitor of poly(ADP-ribose) polymerase, enhances tumor response to doxorubicin. Invest New Drugs. 2008 Feb;26(1):1-5. Epub 2007 Jul 13.
- Shipping Conditions: Room temperature
- Clinical Information: Phase 2